上海莼试生物技术有限公司
上海莼试生物技术有限公司
| 规格 | 5mg 10mg 25mg 50mg 100mg |
| CAS | 342639-96-7 |
| 别名 | N/A |
| 化学名 | N/A |
| 分子式 | C13H12N6O2 |
| 分子量 | 284.27 |
| 溶解度 | DMSO : ≥ 27 mg/mL (94.98 mM) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述：
KRIBB11 is an inhibitor of Heat shock factor 1 (HSF1), with IC50 of 1.2 uM.
KRIBB11 blocks the induction of HSF1 downstream target proteins such as HSP27 and HSP70. KRIBB11 induces growth arrest and apoptosis of HCT-116 cells. KRIBB11 inhibits HSF1-dependent recruitment of p-TEFb (positive transcription elongation factor b) to the hsp70 promoter[1]. PARP and caspase-3 cleavage is increased in cells treated with KRIBB11. Incubating RKO with KRIBB11, shows a toxic threshold of about 10 uM, and an IC50 of 20-30 uM[2].
KRIBB11 (50 mg/kg, i.p.) results in a 47.4% inhibition of tumor growth in nude mice, without body weight loss[1].
1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
标签：KRIBB11
联系人：高小姐
手 机：13585831301
Q Q：3004967995
座 机：021-59541103
传 真：021-60443211
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