KRIBB11CS-01Y65790_上海莼试生物技术有限公司

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一、概述：

化学性质：

规格	5mg 10mg 25mg 50mg 100mg
CAS	342639-96-7
别名	N/A
化学名	N/A
分子式	C13H12N6O2
分子量	284.27
溶解度	DMSO : ≥ 27 mg/mL (94.98 mM)
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

产品描述：

KRIBB11 is an inhibitor of Heat shock factor 1 (HSF1), with IC50 of 1.2 uM.

KRIBB11 blocks the induction of HSF1 downstream target proteins such as HSP27 and HSP70. KRIBB11 induces growth arrest and apoptosis of HCT-116 cells. KRIBB11 inhibits HSF1-dependent recruitment of p-TEFb (positive transcription elongation factor b) to the hsp70 promoter[1]. PARP and caspase-3 cleavage is increased in cells treated with KRIBB11. Incubating RKO with KRIBB11, shows a toxic threshold of about 10 uM, and an IC50 of 20-30 uM[2].

KRIBB11 (50 mg/kg, i.p.) results in a 47.4% inhibition of tumor growth in nude mice, without body weight loss[1].

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标签：KRIBB11

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