GSK-872CS-01Y65781_上海莼试生物技术有限公司

产品详情

一、概述：

化学性质：

规格	5mg 10mg 25mg 50mg 100mg
CAS	1346546-69-7
别名	N/A
化学名	N/A
分子式	C19H17N3O2S2
分子量	383.49
溶解度	DMSO : ≥ 100 mg/mL (260.76 mM)
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

产品描述：

GSK-872 is a RIPK3 inhibitor, which binds RIP3 kinase domain with an IC50 of 1.8 nM, and inhibits kinase activity with an IC50 of 1.3 nM.

GSK-872 blocks necroptosis in mouse cells. RIP3i GSK-872 inhibits TLR3- or DAI-induced death, two RIP1-independent pathways of necroptosis[1]. Pretreatment with GSK-872 (GSK-872) confers significant protection to primary hepatocytes. However, RIPK1 inhibition (by Nec1) does not impart any protection to primary hepatocytes[2].

特别提醒：

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。

2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。

标签：GSK-872

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抑制剂 > 凋亡抑制类 > GSK-872

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产品详情

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