Forodesine hydrochloride (BCX-1777)CS-01Y65776_上海莼试生物技术有限公司

产品详情

一、概述：

化学性质：

规格	1mg 5mg 10mg 25mg 50mg
CAS	284490-13-7
别名	N/A
化学名	N/A
分子式	C11H15ClN4O4
分子量	302.71
溶解度	H2O : ≥ 74.1 mg/mL (244.79 mM)
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

产品描述：

Forodesine hydrochloride is a potent and oral purine nucleoside phosphorylase (PNP) inhibitor with IC50s ranging from 0.48 to 1.57 nM.

[1]. Homminga I, et al. In vitro efficacy of forodesine and nelarabine (ara-G) in pediatric leukemia. Blood. 2011 Aug 25;118(8):2184-90. [2]. Ogura M, et al. Phase I study of BCX1777 (forodesine) in patients with relapsed or refractory peripheral T/natural killer-cell malignancies. Cancer Sci. 2012 Jul;103(7):1290-5. [3]. Bieghs L, et al. The effects of forodesine in murine and human multiple myeloma cells. Adv Hematol. 2010;2010:131895. [4]. Yamauchi T, et al. A nelarabine-resistant T-lymphoblastic leukemia CCRF-CEM variant cell line is cross-resistant to the purine nucleoside phosphorylase inhibitor forodesine. Anticancer Res. 2014 Sep;34(9):4885-92.

特别提醒：

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。

2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。

标签：Forodesine hydrochloride (BCX-1777)

热卖产品最新促销最新推荐

抑制剂 > 凋亡抑制类 > Forodesine hydrochloride (BCX-1777)

产品简介

产品详情

一、概述：

联系我们