上海莼试生物技术有限公司
上海莼试生物技术有限公司
| 规格 | 10mM (in 1mL DMSO) 10mg 50mg |
| CAS | 865362-74-9 |
| 别名 | N/A |
| 化学名 | 5-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-amine |
| 分子式 | C18H13N7 |
| 分子量 | 327.34 |
| 溶解度 | ≥ 10.25mg/mL in DMSO, ≥ 4.47 mg/mL in EtOH with ultrasonic |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述：
FR 180204 is an ATP-competitive and selective ERK inhibitor. FR 180204 inhibits ERK1 and ERK2 with IC50s of 0.51 μM (Ki=0.31 μM) and 0.33 μM (Ki=0.14 μM), respectively[1].
In AP-1-transfected cells, FR180204 dose-dependently inhibits AP-1 transactivation with IC50 of 3.1 μM[1]. FR 180204 inhibits spontaneous mesothelioma cell growth[3].
FR180204 (100 mg/kg, i.p., b.i.d.) significantly decreases the severity of symptoms and body weight loss in collagen-induced arthritis mice[2]. In a mouse model of dengue virus (DENV) infection, FR180204 limits hepatocyte apoptosis, reduces DENV-induced liver injury, and improves clinical parameters[4].
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2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
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