DidesmethylrocaglamideCS-01Y65371_上海莼试生物技术有限公司

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一、概述：

化学性质：

规格	5mg 10mg 25mg 50mg 100mg
CAS	177262-30-5
别名	N/A
化学名	N/A
分子式	C27H27NO7
分子量	477.51
溶解度	DMSO: 100 mg/mL (209.42 mM)
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

产品描述：

Didesmethylrocaglamide, a derivative of Rocaglamide, is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor. Didesmethylrocaglamide has potent growth-inhibitory activity with an IC50 of 5 nM. Didesmethylrocaglamide suppresses multiple growth-promoting signaling pathways and induces apoptosis in tumor cells. Antitumor activity[1].

[1]. Long-Sheng Chang, et al. Targeting Protein Translation by Rocaglamide and Didesmethylrocaglamide to Treat MPNST and Other Sarcomas. Mol Cancer Ther. 2020 Mar;19(3):731-741.

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标签：Didesmethylrocaglamide

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