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Didemnin B is a depsipeptide that has been found in sea squirts and has diverse biological activities.1,2 It reduces viral titers of coxsackievirus A21, equine rhinovirus, parainfluenza virus 3, herpes simplex virus 1 (HSV-1), and HSV-2 in infected Vero cells when used at a concentration of 50 µg/ml.1 Didemnin B is cytotoxic to murine L1210 lymphocytic leukemia cells (IC50 = 1.1 ng/ml) and increases survival time in a P388 murine leukemia model when administered at a dose of 0.06 mg/kg. It also reduces splenomegaly in a mouse model of graft versus host reaction (GVHR) when administered at doses ranging from 0.05 to 0.3 mg/kg.2

1.Rinehart, K.L., Jr., Gloer, J.B., Hughes, R.G., Jr., et al.Didemnins: Antiviral and antitumor depsipeptides from a Caribbean tunicateScience212(4497)933-935(1981) 2.Montgomery, D.W., and Zukoski, C.L.Didemnin B: A new immunosuppressive cyclic peptide with potent activity in vitro and in vivoTransplantation40(1)49-56(1985)

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