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抑制剂 > 蛋白酵素 > Ac-DEVD-CHO (trifluoroacetate salt)
产品名称:
Ac-DEVD-CHO (trifluoroacetate salt)
型号:
CS-01Y65248
生产地址
进口、国产
产品价格
电议
产品简介
质量保证、价格优惠
产品详情

一、概述:

化学性质:                                                                                                             

规格

500μg 1mg 5mg 10mg

CAS

N/A

别名

N/A

化学名

N/A

分子式

C20H30N4O11?XCF3COOH

分子量

502.5

溶解度

DMF: 25 mg/ml,DMSO: 25 mg/ml,Ethanol: 30 mg/ml,PBS (pH 7.2): 10 mg/ml

储存条件

-20°C

General tips

For obtaining a higher solubility , please warm the tube at 37 and shake it in the ultrasonic bath for a while.

Shipping Condition

Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

 

产品描述:                                                                                                             

Ac-DEVD-CHO is a potent inhibitor of the Group II caspases, caspase-3 and caspase-7 (Kis = 0.23 and 1.6 nM, respectively).1,2 Notably, it also inhibits other caspases (Kis = 18, 1710, 132, 205, 31, 0.92, 60, and 12 nM for caspases-1, -2, -4, -5, -6, -8, -9, and -10, respectively).1 Caspase inhibitors in the aldehyde form, like this compound, are typically reversible, whereas methyl ketone forms, like Ac-DEVD-CMK , are irreversible.1 Caspase inhibitors interfere with the initiation of apoptosis and have numerous possible clinical applications.3

1.Garcia-Calvo, M., Peterson, E.P., Leiting, B., et al.Inhibition of human caspases by peptide-based and macromolecular inhibitorsJ. Biol. Chem.273(49)32608-32613(1998) 2.Talanian, R.V., Quinlan, C., Trautz, S., et al.Substrate specificities of caspase family proteasesJ. Biol. Chem.272(15)9677-9682(1997) 3.Nicholson, D.W., Ali, A., Thornberry, N.A., et al.Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosisNature37637-43(1995)

 

特别提醒:                                                                                                              

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗,食品及化妆品等用途。请勿存放于普通住宅区。

2. 为了您的安全和健康,请穿好实验服并佩戴一次性手套和口罩操作。

标签:Ac-DEVD-CHO (trifluoroacetate salt) 

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