ATRA-BA HybridCS-01Y65237_上海莼试生物技术有限公司

产品详情

一、概述：

化学性质：

规格	1 mg 5 mg 10 mg
CAS	1037543-26-2
别名	N/A
化学名	N/A
分子式	C31H40O4
分子量	476.7
溶解度	DMSO: 5 mg/ml
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

产品描述：

ATRA-BA hybrid is a mutual prodrug form of all-trans retinoic acid and butyric acid .1 ATRA-BA hybrid is cleaved to release ATRA and BA in isolated mouse plasma. It inhibits the growth of MDA-MB-231 breast and PC3 prostate cancer cells with GI50 values of 0.01 and 1.02 µM, respectively. ATRA-BA (20 µM) has 15-fold greater antiproliferative activity in PC3 cells compared to an equimolar concentration of ATRA and BA.

1.Gediya, L.K., Khandelwal, A., Patel, J., et al.Design, synthesis, and evaluation of novel mutual prodrugs (hybrid drugs) of all-trans-retinoic acid and histone deacetylase inhibitors with enhanced anticancer activities in breast and prostate cancer cells in vitroJ. Med. Chem.51(13)3895-3904(2008)

特别提醒：

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。

2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。

标签：ATRA-BA Hybrid

热卖产品最新促销最新推荐

抑制剂 > 蛋白酵素 > ATRA-BA Hybrid

产品简介

产品详情

一、概述：

联系我们