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Albofungin is a xanthone isolated from A. tumemacerans with diverse biological activities. It inhibits the growth of various Gram-positive bacteria (MICs = 0.005-7.5 μg/ml), fungi (MICs = 0.0075-1.0 μg/ml), and mycobacteria (MICs = 1.0-10.0 μg/ml) with minimal activity against Gram-negative bacteria (MICs = ≥ 50.0 μg/ml). At concentrations ranging from 0.005 to 0.01 μg/ml, albofungin is cytotoxic to HeLa cells. It also inhibits HIV reverse transcriptase with an IC50 value of 1 μM.

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