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Amycolatopsin A is a macrolide polyketide originally isolated from Amycolatopsis that has antimycobacterial and anticancer activities.1 It is active against M. bovis and M. tuberculosis (IC50s = 0.4 and 4.4 µM, respectively) but not B. subtilis, S. aureus, E. coli, or P. aeruginosa (IC50s = >30 µM for all). Amycolatopsin A is cytotoxic to SW620 colorectal and NCI H460 lung cancer cells (IC50s = 0.08 and 1.2 µM, respectively).

1.Khalil, Z.G., Salim, A.A., Vuong, D., et al.Amycolatopsins A-C: Antimycobacterial glycosylated polyketide macrolides from the Australian soil Amycolatopsis sp. MST-108494J. Antibiot. (Tokyo)70(12)1097-1103(2017)

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