4-oxo-27-TBDMS Withaferin ACS-01Y65071_上海莼试生物技术有限公司

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化学性质：

规格	1mg 5mg 10mg
CAS	1214886-31-3
别名	N/A
化学名	N/A
分子式	C34H50O6Si
分子量	582.9
溶解度	DMF: 5mg/mL,DMSO: 5mg/mL,DMSO:PBS (pH 7.2) (1:1): 0.5mg/mL
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

产品描述：

4-oxo-27-TBDMS Withaferin A is a derivative of the steroidal lactone withaferin A that has anticancer activity.1 It is cytotoxic to A2780 ovarian cancer cells (IC50 = 17 μM) but not to carboplatin-resistant A2780 (A2780/CP70) cells (IC50 = >100 μM). It is selective for A2780 cells over non-cancerous ARPE19 cells (IC50 = 1,660 μM). 4-oxo-27-TBDMS Withaferin A induces DNA fragmentation in A2780 cells.

References

1. Perestelo, N.R., Llanos, G.G., Reyes, C.P., et al. Expanding the chemical space of withaferin A by incorporating silicon to improve its clinical potential on human ovarian carcinoma cells. J. Med. Chem. 62(9), 4571-4585 (2019).

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标签：4-oxo-27-TBDMS Withaferin A

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