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Astragalin is an inhibitor of eotaxin-1, PKCβ2 phosphorylation, activation of NF-κB/MAPK and PLCγ1 that correlated with oxidase in a dose dependent manner [1] [2].

Oxidative stress means disturbances in the normal redox state of cells can cause toxic effects through the production of peroxides and free radicals that damage all components of the cell. And it is reported that oxidative stress can cause disruptions in normal mechanisms of cellular signaling, such as cancer development, Parkinson's disease, Alzheimer's disease, atherosclerosis, passive cutaneous reactions, inflammation, heart failure, myocardial infarction, Sickle Cell Disease, infection, and chronic fatigue syndrome [1, 3]. In human osteoaithritis chondrocyte cells, astragalin inhibited the activation of NF-κB and MAPK [2].

Astragalin is reported to have the ability of anti-oxidant effect. When tested with human basophilic cell line KU812, oral administration of astragalin inhibited the release of histamine and passive cutaneous reactions [4]. In airway epithelial BEAS-2B cells, astragalin treatment antagonized endotoxin-induced oxidative stress that is responsible to airway dysfunction and inflammation [1]. When tested with human red blood cells induced in the oxidative state, administration of astragalin suppressed the [3].

In mouse model with NC/Nga atopic dermatitis, astragalin treatment significantly suppressed the dermatitis development, scratching behavior and serum IgE elevation [4].

References:

[1].    Cho, I.H., et al., Astragalin inhibits airway eotaxin-1 induction and epithelial apoptosis through modulating oxidative stress-responsive MAPK signaling. BMC Pulm Med, 2014. 14: p. 122.

[2].    Ma, Z., et al., Astragalin inhibits IL-1beta-induced inflammatory mediators production in human osteoarthritis chondrocyte by inhibiting NF-kappaB and MAPK activation. Int Immunopharmacol, 2015. 25(1): p. 83-87.

[3].    Choi, J., et al., Antioxidant effect of astragalin isolated from the leaves of Morus alba L. against free radical-induced oxidative hemolysis of human red blood cells. Arch Pharm Res, 2013. 36(7): p. 912-7.

[4].    Kotani, M., et al., Persimmon leaf extract and astragalin inhibit development of dermatitis and IgE elevation in NC/Nga mice. J Allergy Clin Immunol, 2000. 106(1 Pt 1): p. 159-66.

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