化学性质:
规格 | 25μg 50μg 100μg |
CAS | 83851-42-7 |
别名 | LTF4 |
化学名 | 5S-hydroxy-6R-(S-γ-glutamylcysteinyl)-7E,9E,11Z,14Z-eicosatetraenoic acid |
分子式 | C28H44N2O8S |
分子量 | 568.7 |
溶解度 | >50 mg/ml (per Ramki Iyer) in DMSO, >50 mg/ml (per Ramki Iyer) in DMF, >50 mg/ml (per Ramki Iyer) in Ethanol |
储存条件 | Store at -80°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述:
LTF4 is a cysteinyl-leukotriene produced in vitro, but not reported to date in vivo. It is formed by the incubation of LTE4 with γ-glutamyl transpeptidase and glutathione. LTF4 is a weak agonist in its ability to contract vascular smooth muscle. [1] The rank order of potency of the cysteinyl-leukotrienes to contract vascular smooth muscle is LTD4 > LTC4 > LTE4 >> LTF4. [1] [2]
Reference:
[1]. Bernstrom, K., and Hammarstr?m, S. A novel leukotriene formed by transpeptidation of leukotriene E4. Biochemical and Biophysical Research Communications 109, 800-804 (1982).
[2]. Lord, A., Charleson, S., and Letts, L.G. Leukotriene F4 and the release of arachidonic acid metabolites from perfused guinea pig lungs in vitro. Prostaglandins 29, 651-660 (1985).
特别提醒:
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标签:Leukotriene F4
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