Hydroxy CelecoxibCS-01Y64928_上海莼试生物技术有限公司

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一、概述：

化学性质：

规格	5 mg 10 mg 25 mg 50 mg
CAS	170571-00-3
别名	N/A
化学名	N/A
分子式	C17H14F3N3O3S
分子量	397.4
溶解度	DMSO: slightly soluble,Methanol: slightly soluble
储存条件	Store at-20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

产品描述：

Hydroxy celecoxib is an inactive metabolite of celecoxib .1 It is formed from celecoxib by the cytochrome P450 (CYP) isoforms CYP2C9, CYP3A4, and CYP2D6 in human liver microsomes.2

1.Penning, T.D., Talley, J.J., Bertenshaw, S.R., et al.Synthesis and biological evaluation fo the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: Identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide (SC-58635, celecoxib)J. Med. Chem.40(9)1347-1365(1997) 2.Siu, Y.A., Hao, M.-H., Dixit, V., et al.Celecoxib is a substrate of CYP2D6: Impact on celecoxib metabolism in individuals with CYP2C9*3 variantsDrug Metab. Pharmacokinet.33(5)219-227(2018)

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1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。

2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。

标签：Hydroxy Celecoxib

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