MEGX (hydrochloride)CS-01Y64882_上海莼试生物技术有限公司

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一、概述：

化学性质：

规格	1mg 5mg 10mg 25mg
CAS	7729-94-4
别名	N/A
化学名	N/A
分子式	C12H18N2O.HCl
分子量	242.7
溶解度	DMF: 1 mg/ml,DMSO: 5 mg/ml,Ethanol: 2 mg/ml,PBS (pH 7.2): 5 mg/ml
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

产品描述：

MEGX is an active metabolite of lidocaine.1 It is formed via N-deethylation of lidocaine by the hepatic cytochrome P450 (CYP) isoform CYP3A4. Topical administration of MEGX (2% v/v) reduces thrombus formation in a hamster model of laser-induced microvascular injury.2 Plasma levels of MEGX following lidocaine administration have been used to monitor declining liver function in patients with cirrhosis.1

References

1. Reichel, C., Skodra, T., Nacke, A., et al. The lignocaine metabolite (MEGX) liver function test and P-450 induction in humans. Br. J. Clin. Pharmacol. 46(6), 535-539 (1998).

2. Luostarinen, V., Evers, H., Lyytik?inen, M.T., et al. Antithrombotic effects of lidocaine and related compounds on laser-induced microvascular injury. Acta Anaesthesiol. Scand. 25(1), 9-11 (1981).

特别提醒：

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。

2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。

标签：MEGX (hydrochloride)

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