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Hydrocortisone acetate is a synthetic corticosteroid.1,2 Topical administration of hydrocortisone acetate (0.1% v/v) reduces corneal haze and hydroxyproline levels without reducing the stromal wound healing response in a rabbit model of photorefractive keratectomy.1 Hydrocortisone acetate enhances and reduces cartilage degradation in a mouse model of air pouch cartilage implantation when injected into the air pouch cavity or into the air pouch lining tissue, respectively.2 Formulations containing hydrocortisone acetate have been used in the treatment of joint inflammation and rheumatoid arthritis.

|1. Bilgihan, K., Ozdek, S., Ozo?ul, C., et al. Topical vitamin E and hydrocortisone acetate treatment after photorefractive keratectomy. Eye (Lond) 14(Pt 2), 231-237 (2000).|2. Sedgwick, A.D., Sin, Y.M., Moore, A.R., et al. Effects of local administration of hydrocortisone on cartilage degradation in vivo. Ann. Rheum. Dis. 43(3), 418-420 (1984).