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抑制剂 > 蛋白酵素 > Diapocynin
产品名称:
Diapocynin
型号:
CS-01Y64677
生产地址
进口、国产
产品价格
电议
产品简介
质量保证、价格优惠
产品详情

一、概述:

化学性质:                                                                                                             

规格

1mg 5mg 10mg 25mg

CAS

29799-22-2

别名

N/A

化学名

1,1'-(6,6'-dihydroxy-5,5'-dimethoxy[1,1'-biphenyl]-3,3'-diyl)bis-ethanone

分子式

C18H18O6

分子量

330.3

溶解度

DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml,Ethanol: 20 mg/ml

储存条件

Store at -20°C

General tips

For obtaining a higher solubility , please warm the tube at 37 and shake it in the ultrasonic bath for a while.

Shipping Condition

Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

 

 产品描述:                                                                                                             

Diapocynin is the dimeric form of the NADPH oxidase inhibitor apocynin that has anti-inflammatory and antioxidant activities. Diapocynin inhibits NADPH oxidase complex assembly and activation, gp91phox mRNA expression, and production of the pro-inflammatory cytokines TNF-α and IL-10 in peripheral blood mononuclear cells (PMBCs). It inhibits production of reactive oxygen species (ROS), calcium-independent isoform of phospholipase A2 (iPLA2) function, and reduces Ca2+ influx through store-operated and stretch-activated channels (SOCs and SACs, respectively) in dystrophic myotubes; all functions in the pathogenic cascade leading to muscular dystrophy. Diapocynin also reverses motor coordination deficits in the LRRK2R1441G mouse model of early Parkinson's disease.

特别提醒:                                                                                                              

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗,食品及化妆品等用途。请勿存放于普通住宅区。

2. 为了您的安全和健康,请穿好实验服并佩戴一次性手套和口罩操作。

标签:Diapocynin 

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