CTTHWGFTLC, CYCLIC TFA is a cyclic peptide inhibitor for matrix metalloproteinases MMP-2 and MMP-9. The IC50 value for MMP-9 is ~8 μM[1].

CTTHWGFTLC, CYCLIC TFA inhibits endothelial and tumor cell migration in vitro[1].

CTTHWGFTLC, CYCLIC TFA inhibits tumor progression in vivo, in mouse models[1].

[1]. Medina OP, et al. Binding of novel peptide inhibitors of type IV collagenases to phospholipid membranes and use in liposome targeting to tumor cells in vitro. Cancer Res. 2001 May 15;61(10):3978-85.

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