H-HoArg-OH, a homologue arginine, is a strong inhibitor of human bone and liver alkaline phosphatase.

It is found that H-HoArg-OH (L-homoarginine), a homologue of arginine, is a strong inhibitor of human bone and liver alkaline phosphatase while it has virtually no effect on intestinal and placental alkaline phosphatases unlike H-HoArg-OH which inhibits intestinal and placental alkaline phosphatases but not the liver and bone enzymes. These four tissues mentioned are the major contributors to the serum alkaline phosphatase[1]. It is also indicated that low levels of the endogenous amino acid H-HoArg-OH are linked to cardiovascular disease[2].

References:

[1]. Fishman W, et al. L-homoarginine; an inhibitor of serum "bone and liver" alkaline phosphatase. Clin Chim Acta. 1970 Aug;29(2):339-41.

[2]. Atzler D, et al. L-homoarginine and cardiovascular disease. Curr Opin Clin Nutr Metab Care. 2015 Jan;18(1):83-8.

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