FOY 251 is an anti-proteolytic active metabolite camostate , acts as a proteinase inhibitor[1][2].FOY 251 inhibit SARS-CoV-2 infection in cells assay[1][3].

FOY-251 represents a dose-dependent inhibition of equivalent current in M-1 cells[2].FOY-251 inhibits the proteolytic activity of prostasin[2].

[1]. K Beckh, et al. Elimination of the Low-Molecular Weight Proteinase Inhibitor Camostate (FOY 305) and Its Degradation Products by the Rat Liver. Res Exp Med (Berl). 1987;187(6):401-6. [2]. Ai Maekawa, et al. Camostat Mesilate Inhibits Prostasin Activity and Reduces Blood Pressure and Renal Injury in Salt-Sensitive Hypertension. J Hypertens . 2009 Jan;27(1):181-9. [3]. Markus Hoffmann, et al. Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity. bioRxiv. 2020 Aug 5;2020.08.05.237651.

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