规格 | 1g |
CAS | 110-94-1 |
别名 | N/A |
化学名 | N/A |
分子式 | C5H8O4 |
分子量 | 132.12 |
溶解度 | DMSO: 125 mg/mL (946.11 mM) |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述:
Glutaric acid induces oxidative stress in brain of young rats.
Glutaric acid (GA) at concentrations of 1 and 2 mM is able to reduce TRAP measurement by up to 28% in a dose-dependent manner (β=0.77; P<0.001). Furthermore, a significantly inverse correlation is also verified between chemiluminescence and TRAP (β=0.81; P<0.001). Glutaric acid does not alter the activities of Cat and SOD, but strongly inhibits (up to 46%) the activity of GPx even at the lower concentration used (0.5 mM). It is observed that the metabolite inhibits this activity in a dose-dependent manner at concentrations as low as 0.05 mM[1].
[1]. de Oliveira Marques F, et al. acid induces oxidative stress in brain of young rats. Brain Res. 2003 Feb 21;964(1):153-8.
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