Carbofuran is a carbamate insecticide that inhibits acetylcholinesterase (AChE) in insects and mammals (Kas = 9.4, 30, and 210 μM for M. domestica brain, A. mellifera brain, and bovine erythrocyte AChE, respectively).1 It also inhibits AChE from rat and human erythrocytes with IC50 values of 40 and 25 nM, respectively.2 It is toxic to the housefly M. domestica (LD50 = 4.6 mg/kg) and fourth-instar larvae of the mosquito C. pipiens with an LC50 value of 0.054 ppm. Carbofuran is toxic to birds, rats (LD50 = 4-11 mg/kg), and other mammals including dogs, sheep, and cattle, and is considered an environmental toxin.1,3 Formulations containing carbofuran have been used in agriculture for the control of insects, nematodes, mites, and ticks.

1.Yu, C., Metcalf, R.L., and Booth, G.M.Inhibition of acetylcholinesterase from mammals and insects by carbofuran and its related compounds and their toxicities toward these animalsJ. Agric. Food Chem.20(5)923-926(1972) 2.Rao, P.S., Roberts, G.H., Pope, C.N., et al.Comparative inhibition of rodent and human erythrocyte acetylcholinesterase by carbofuran and carbarylPestic. Biochem. Physiol.48(2)79-84(1994) 3.Gupta, R.C.Carbofuran toxicityJ. Toxicol. Environ. Health43(4)383-418(1994)

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