ATP is a central component of energy storage and metabolism in vivo, provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. Human Endogenous Metabolite

ATP (100-300?&#181M) inhibits the production of TNF-α by 32±8%, and at 300?&#181M, the attenuation of TNF-α production is 65±4% in LPS + PHA-stimulated whole blood. ATP (100, 300 &#181M) increases IL-10 levels by 48±5% (p=0.01) and 62±7%, respectively, in LPS + PHA-stimulated whole blood. ATP does not significantly alter the production of IL-6[1].

[1]. Swennen EL, et al. Immunoregulatory effects of adenosine 5’-triphosphate on cytokine release from stimulated whole blood. Eur J Immunol. 2005 Mar;35(3):852-8.

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