Amobarbital (sodium salt) is an analytical reference standard that is categorized as a barbiturate. By activating GABAA receptors in rat thalamic slices, 100 μM amobarbital elicits a depressant effect, increasing both the amplitude and decay time of inhibitory postsynaptic currents.1 It has also been shown to compete with rotenone for binding at complex I to inhibit mitochondrial electron transport.2 Amobarbital is regulated as a schedule II compound in the United States and intended only for forensic and research purposes.
1.Kim, H.S., Wan, X., Mathers, D.A., et al.Selective GABA-receptor actions of amobarbital on thalamic neuronsBr.J.Pharmac.143(4)485-494(2004) 2.Chen, A., Hoppel, C.L., and Lesnefsky, E.J.Blockade of electron transport before cardiac ischemia with the reversible inhibitor amobarbital protects rat heart mitochondriaJournal of Pharmacology and Experimental Therapeutics316(1)200-207(2006)

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