Abametapir is a building block and an insectide.1,2,3 It has been used in the synthesis of lanthanide coordination complexes with antifungal activity against C. albicans and divalent vancomycin derivatives with antibacterial activity against vancomycin-resistant enterococci.1,2 Abametapir is ovicidal to DDT- and permethrin-resistant head louse eggs (LC50s = 0.108, 0.121, and 0.16% in isopropanol for 0-2-, 3-5-, and 6-8-day-old eggs, respectively).3 Formulations containing abametapir have been used in the topical treatment of head lice infestation.
1.Zhou, M.-X., Ren, N., Zhang, J.-J., et al.Synthesis, crystal structure, thermal, luminescent property and antibacterial activity of lanthanide ternary complexes with p-chlorobenzoic acid and 5,5′-dimethyl-2,2′-bipyridineJ. Mol. Struct.1200127049(2020) 2.Xing, B., Yu, C.-W., Ho, P.-L., et al.Multivalent antibiotics via metal complexes: Potent divalent vancomycins against vancomycin-resistant enterococciJ. Med. Chem.46(23)4904-4909(2003) 3.Bowles, V.M., Yoon, K.S., Barker, S.C., et al.Ovicidal efficacy of abametapir against eggs of human head and body lice (Anoplura: Pediculidae)J. Med. Entomol.54(1)167-172(2017)

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